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Southeast Asian J Trop Med Public Health ; 2006 Jul; 37(4): 619-21
Article in English | IMSEAR | ID: sea-33232

ABSTRACT

Concanamycin A, a macrolide antibiotic inhibitor of vacuolar H+-ATPase derived from Streptomyces sp, inhibited Plasmodium falciparum K1 growth in culture with an IC500 value of 0.2 nM. It exhibited an additive effect when tested together with the antimalarial pyronaridine.


Subject(s)
Animals , Antimalarials/toxicity , Inhibitory Concentration 50 , Macrolides/toxicity , Naphthyridines/toxicity , Plasmodium falciparum/drug effects
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